ArticleFrontiers in immunology2025
Tertiary lymphoid structure drives allograft rejection via IFN-γ-JAK-STAT-dependent atypical memory B cell differentiation.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Regulation of follicular helper T cell subset differentiation in health and disease.Journal of molecular medicine (Berlin, Germany) · 2026Review
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6 authors.
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Abstract
Background: Tertiary lymphoid structure (TLS) is a neogenized, ectopic lymphoid aggregate found in infected, autoimmune and tumour tissues with an activated adaptive immune response. However, a comprehensive understanding of the pathological role, function, and formation of TLS in allograft rejection remains incomplete. Methods: We enrolled two large retrospective cohorts of liver biopsy (LB) after pediatric living donor liver transplantation (LDLT) and developed a deep learning pathomics (DLP) model. Gene expression profiles and corresponding clinical information of 590 cases were enrolled from three transcriptomic databases, including cohort-GSE193135 (n=337), cohort-GSE145780 (n=235), cohort-Renji (n=18). ESTIMATE, CIBERSORT, XCELL and MCP analyses were performed to visualize the immune landscape. Single-cell RNA-sequencing (scRNA-seq) analysis of 11 LBs after LDLT and multiplexed immunohistochemistry (mIHC) were performed to validate the discoveries of bioinformatics analysis. Results: We provided evidence that increased TLS in the liver was closely correlated with allograft rejection, fibrosis, and declined liver function. ScRNA-seq and Conclusion: We proposed an efficient DLP model for predicting allograft rejection, and revealed an unexpected immunological mechanism of TLS in allograft rejection livers and clarified an IFN-γ-JAK-STAT-dependent circuit that could be targeted with drugs and transformed AtM B cells into potent instigators of hepatocellular injury in allograft rejection.
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