ArticleThe journal of allergy and clinical immunology. Global2026
Global variations of IgE cross-reactivity in Cupressus allergy.
Article in The journal of allergy and clinical immunology. Global, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Seasonal allergic rhinitis triggered by Cupressaceae species is a significant concern worldwide, particularly in regions such as Japan, China, Spain, and the United States. Objective: This study investigated specific IgE responses to Cupressaceae species and the potential clinical relevance of cross-reactivity, focusing on Japanese cedar ( Methods: We analyzed serum samples from 609 patients across 4 countries to measure levels of specific IgE using ImmunoCAP. We assessed IgE reactivity against Cry j extract and other Cupressaceae species, including Arizona cypress and red cedar extracts, to delineate patterns of reactivity. Results: Levels of specific IgE against Cry j were markedly elevated in Japanese samples; they were nearly 10-fold higher than those against other allergens. In contrast, samples from China, Spain, and the United States showed lower levels of Cry j-specific IgE, with significant levels of reactivity against Conclusion: These findings indicate notable geographic variations in specific IgE reactivity and cross-reactivity among Cupressaceae species, thus underscoring the importance of tailoring diagnostic and therapeutic approaches in allergy treatment based on region-specific allergen exposure patterns.
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