Evidence map›Paper›PMID 41459394›Full record

ArticleBioactive materials2026

Engineering macromolecular crowding-driven amyloid-mineral hybrid scaffolds for enhanced bone regeneration.

Yangyang Ye, Xuewen Li, He Feng, Shan Zhang, Xinye Zhou, Min Li, Fan Li, Cheng Zhi, Zeyuan Chen, Xiangyu Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yangyang YeTianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, PR China.
Xuewen LiTianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, PR China.
He FengTianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, PR China.
Shan ZhangTianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, PR China.
Xinye ZhouTianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, PR China.
Min LiTianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, PR China.
Fan LiTianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, PR China.
Cheng ZhiNational Center of Stomatology, School and Hospital of Stomatology, Peking University, Beijing, 100081, PR China.
Zeyuan ChenTianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, PR China.
Xiangyu ZhangTianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, PR China.
Zhongze FangDepartment of Toxicology and Health Inspection and Quarantine, Tianjin Key Laboratory of Environment, Nutrition and Public Health, School of Public Health, Tianjin Medical University, Tianjin, 300070, PR China.
Fuchun FangDepartment of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China.
Peng YangKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Xi'an Key Laboratory of Polymeric Soft Matter, International Joint Research Center on Functional Fiber and Soft Smart Textile, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, PR China.
Xu ZhangTianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extracellular matrix (ECM) of native bone features a densely crowded, hierarchically organized architecture composed of collagen fibrils and hydroxyapatite (HAp) nanocrystals, which together confer mechanical strength and biological functionality. However, faithfully replicating this complex organic-inorganic interface in synthetic scaffolds remains a significant challenge. Here, we report a macromolecular crowding (MMC)-driven strategy to construct ECM-mimetic scaffolds using phase-transited lysozyme (PTL) as an amyloid-based protein matrix. By employing a reverse dialysis process to mimic the crowded microenvironment, amyloid proteins undergo aggregation, conformational rearrangement, and a liquid-crystalline-like phase transition, accompanied by reconstruction of the organic-inorganic interface and energetic reorganization, thereby promoting biomineralization. The resulting amyloid-mineral hybrid scaffold exhibits excellent structural stability, mechanical robustness, and bioactivity, supporting bone regeneration comparable to mineralized collagen

Indexed as

Amyloid proteinsBiomimetic biomineralizationBone regenerationMolecular crowdingOrganic–inorganic hybridsTissue engineering

Identifiers

PMID41459394
PMCPMC12743378

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.