ArticleFrontiers in microbiology2025
Association between infants' serum levels of 26 metals and gut microbiota: a hospital-based cross-sectional study in China.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study examined the associations of toxic metals, essential metals, and rare earth elements with infant gut microbiota at Hunan Children's Hospital, China. Methods: Generalized linear regression (GLR) was used to assess individual metal associations with alpha diversity, whereas Bayesian kernel machine regression (BKMR) and weighted quantile sum (WQS) regression were applied to evaluate metal mixture-taxa relationships. Results: Results showed that barium (Ba) and arsenic (As) were positively associated with the Chao1 index, whereas chromium (Cr), antimony (Sb), tungsten (W), cobalt (Co), copper (Cu), lanthanum (La), praseodymium (Pr), and uranium (U) showed negative associations. Six antagonistic interactions were identified: Cr-W (β = -2.57), Cr-La (β = -3.82), Tl-As (β = -4.48), As-La (β = -4.31), As-Pr (β = -5.85), and La-Pr (β = -2.38). Two synergistic interactions were observed: Sb-Pr (β = 2.17) and Sb-U (β = 2.14). BKMR analysis identified Mn as a key contributor to Discussion: These findings demonstrate that As and Cu are the most influential metals on gut microbial alpha diversity, whereas Cu, As, and Mn significantly influence specific microbial taxa, providing novel epidemiological evidence on metal-gut microbiota interactions in vulnerable infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.