ReviewFrontiers in microbiology2025
Mechanisms of aerobic exercise effects on the gut microbiota and its metabolites in anxiety disorders.
Review in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Mechanism of Exercise-Regulated Intestinal Flora for Alzheimer's Disease Based on Gut-Brain Axis.Nutrients · 2026Review
- Diet, gut microbiota, and the gut-brain axis: mechanistic interactions and therapeutic implications in neuropsychiatric disorders.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anxiety disorders are prevalent and disabling conditions that frequently co-occur with major depression, alcohol and substance abuse disorders, and personality disorders. While psychopharmacological treatments and cognitive-behavioral therapy are the primary interventions for anxiety disorders, up to 30% of patients exhibit inadequate treatment responses, and approximately 40% relapse within the first year after discontinuing medication. Moreover, medication-related side effects have a significant impact on patients' quality of life. These limitations highlight the urgent need for more comprehensive research into the underlying pathophysiology of anxiety disorders to facilitate the development of more effective therapeutic strategies. In this context, aerobic exercise has consistently been linked to improvements in physical health, life satisfaction, cognitive functioning, and psychological wellbeing. Aerobic exercise may serve as an effective and cost-efficient alternative for managing various anxiety disorders. This review explores the potential mechanisms through which aerobic exercise influences anxiety disorders, focusing on its effects on gut microbiota and related metabolites. The findings aim to propose novel therapeutic strategies for patients with anxiety disorders and provide a theoretical foundation for future research in this field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.