Tribulations, Triumphs, and Governance: Shaping the Future of Artificial Intelligence in Healthcare.

Artificial intelligence (AI) is driving a profound transformation across the healthcare landscape, with the potential to enhance diagnostic accuracy, optimize clinical decision-making, improve resource allocation, and advance personalized medicine. In public health, AI is redefining infectious disease epidemiology by enabling outbreak forecasting, genomic surveillance, and data-driven policy support, even in the presence of incomplete information. Within clinical laboratories, AI plays a pivotal and expanding role. It facilitates automation of complex workflows, supports diagnostic interpretation, and contributes to analytical performance improvements. Particularly promising is its integration into point-of-care testing, enabling decentralized diagnostics and broader access to timely care, especially in resource-constrained settings. However, these advancements are not without challenges. Concerns regarding algorithmic bias, lack of data representativeness, and risks to privacy and transparency must be carefully addressed. Moreover, the ethical and societal implications of AI are increasingly central. As emphasized by Pope Francis, while AI may accelerate access to knowledge and innovation, it also risks deepening global disparities and promoting a "throwaway culture" that undermines human dignity. His appeal for a "culture of encounter" rooted in equity, justice, and inclusion aligns with the mission of public health and laboratory medicine. This paper, based on the invited lecture delivered at the Clinical Laboratories Artificial Intelligence Revolution (CLAIR) 2025 conference, explores these themes through a critical lens. International scientific societies such as the IFCC are called to foster equitable implementation of AI by promoting access to training, infrastructure, and governance frameworks thus ensuring that AI contributes meaningfully to global health solidarity and equity.