ArticleEJIFCC2025
Evaluating the Interference of Residual 'Teepol' Detergent on Serum Electrolytes, Protein, and Cholesterol: An In-Vitro Study.
Article in EJIFCC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: In low-resource settings, reusing blood collection tubes cleaned with detergents such as 'Teepol' is common due to economic constraints. However, residual detergent may interfere with biochemical assays. This study evaluated the effect of residual 'Teepol' on serum electrolyte, total protein, and cholesterol, with emphasis on direct ion-selective electrode (ISE) methods. Method: A controlled interference experiment was conducted using pooled human serum spiked with increasing concentrations of 'Teepol' (0%, 0.2%, 0.5%, and 1.0% v/v of original detergent). Serum sodium and potassium were measured using direct ISE (Ortho_Vitros Results: Serum sodium and potassium showed a concentration-dependent decline with increasing 'Teepol'. At 1.0%, sodium decreased by ~12% and potassium by ~43% compared to control, with values falling outside the 95% confidence intervals, confirming significant interference. Total protein and cholesterol measurements remained within expected analytical variation. Strong negative correlations were observed for sodium (R=-0.966) and potassium (R=-0.989) with 'Teepol' concentration (p< 0.05). Conclusion: Residual 'Teepol' ≥0.5% v/v significantly interferes with serum sodium and potassium measurements using direct ISE. These findings highlight the importance of strict tube-washing protocols or the use of disposable tubes for critical assays. Inconsistent cleaning practices in low-resource laboratories may allow such interference, posing a risk to result accuracy and clinical decision-making.
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