ReviewJournal of clinical and experimental dentistry2025
Effect of calcium hypochlorite and sodium hypochlorite on postoperative pain in necrotic pulps: A randomized clinical trial.
Review in Journal of clinical and experimental dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This randomized clinical trial evaluated postoperative pain and analgesic intake in patients with pulp necrosis and asymptomatic chronic apical periodontitis. Material and Methods: Sixty-three patients were randomly assigned to two groups receiving root canal irrigation with either 2.5% calcium hypochlorite (Ca (OCl)2) or 2.5% sodium hypochlorite (NaOCl). Root canal preparation was performed using rotary instruments, and all canals were filled in a single visit. Postoperative pain was assessed using a 0-10 numerical rating scale at 24, 48, and 72 hours, and one-week post-treatment. Analgesic intake was also recorded. Statistical analysis was performed using Fisher's exact test. Results: No significant differences in pain levels were observed between groups at 24 hours (p = 0.601) or other time points. Most patients (95.2%) reported no pain, 3.1% mild pain, and 1.5% severe pain. Analgesic intake was reported by only one patient. Conclusions: Calcium hypochlorite is a promising irrigant for endodontic treatment, showing comparable postoperative pain outcomes to sodium hypochlorite.
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