SynthesisFrontiers in nutrition2025
Effectiveness and safety of dietary supplements in the adjunctive treatment of psoriasis: a systematic review and network meta-analysis.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Psoriasis, a chronic immune-mediated inflammatory skin disease, significantly impairs quality of life. Conventional treatments often pose safety risks or lack long-term efficacy. Dietary supplements show immunomodulatory and anti-inflammatory effects, but their adjunctive role in plaque psoriasis lacks a comprehensive comparison. Methods: A network meta-analysis (NMA) of 21 randomized controlled trials (RCTs), involving 1,463 patients with plaque psoriasis, was conducted using eight international and Chinese databases up to March 3, 2025. Interventions included vitamin D, XP-828L, fish oil, selenium, probiotics, curcumin, and micronutrients. Primary outcomes were Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI), physician global assessment (PGA), interleukins (IL-6, IL-17, IL-23, IL-22), and adverse events. A frequentist NMA in Stata 17.0 used surface under the cumulative ranking curve (SUCRA) to rank efficacy and safety. Results: In 21 RCTs ( Conclusion: Dietary supplements may provide complementary benefits in plaque psoriasis; however, effect estimates vary by outcome, and certainty is low to moderate. Personalization is advisable, and confirmatory, larger RCTs with standardized dosing and longer follow-up are warranted. (Word count: 223). Systematic review registration: The review was registered at INPLASY (INPLASY202570119; DOI:10.37766/inplasy2025.7.0119).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.