ArticleFrontiers in nutrition2025
Metabolic-BMI phenotypes as nutritional risk indicators for osteoarthritis: evidence from a prospective cohort of UK adults.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Obesity-Associated Osteoarthritis: Mechanical-Metabolic Pathogenesis, Obesity Memory and Dual-Target Therapy.Current obesity reports · 2026Review
- APOA4 Protects Chondrocytes and Modulates Wnt Signaling in Osteoarthritis.Journal of inflammation research · 2026Article
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2 authors.
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Abstract
Background: Metabolic health status has emerged as a crucial nutritional and physiological indicator, reflecting the complex interplay between dietary intake, energy metabolism, and chronic disease risk. Obesity is a well-known risk factor for osteoarthritis (OA), yet substantial metabolic heterogeneity exists among individuals with obesity. Understanding how metabolic variability modifies the obesity-OA relationship can provide valuable insights into nutrition-related mechanisms of musculoskeletal health. This study aimed to examine the association between metabolic-BMI phenotypes and incident OA among middle-aged and older adults (MAOA) in the UK. Methods: The ELSA provided the data. Metabolically healthy normal weight (MHNW), metabolically healthy overweight/obesity (MHOO), metabolically unhealthy normal weight (MUNW), as well as metabolically unhealthy overweight/obesity (MUOO) were the four metabolic-BMI phenotypes into which the participants were divided. The relationships between these phenotypes and incident OA were estimated via Cox proportional hazards models, which controlled for clinical variables, lifestyle choices, and sociodemographic traits. Results: During a median follow-up of 10 years, 673 new OA cases were identified. Compared with the MHNW group, participants with MHOO (HR = 1.54, 95% CI: 1.19-2.01, Conclusion: Metabolic status modified-but did not eliminate-the association between obesity and osteoarthritis risk. These findings highlight substantial heterogeneity within obesity phenotypes and suggest that incorporating metabolic health with BMI may improve identification of individuals at elevated OA risk.
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