ArticleFrontiers in veterinary science2025
The subunit vaccine of Lumpy skin disease virus elicits significant humoral and cell-mediated immune responses in mice.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lumpy skin disease (LSD) is an emerging systemic and infectious disease affecting cattle. Currently, there is no specific treatment for this disease, and vaccination to boost immunity remains the most direct and effective approach for preventing LSD. In this study, we selected ORF073, ORF075, ORF090, and ORF110 proteins from the Lumpy skin disease virus (LSDV), which exhibit dominant antigenic properties, to construct, express, and identify recombinant prokaryotic expression vectors. The purified proteins were used to immunize mice. The immune efficacy of the subunit vaccines was preliminarily evaluated by monitoring antibody secretion and the expression of immune-related genes. The results showed that mice immunized with ORF075 and ORF090 subunit vaccines produced higher levels of antibody responses and induced a Th1/Th2-biased immune response. Splenocytes from immunized mice, when stimulated with vaccine antigens
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.