Evidence map›Paper›PMID 41459022›Full record

ArticleJSES international2026

Preoperative testosterone replacement therapy: a potential risk-factor for complications and reoperation after rotator cuff repair.

Andrea H Johnson, Ryan Friedman, Jane C Brennan, Matthew A Peterman, Jeffrey Gelfand, Daniel E Redziniak, Cyrus Lashgari, Justin J Turcotte

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JSES international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrea H JohnsonLuminis Health Anne Arundel Medical Center, Annapolis, MD, USA.
Ryan FriedmanLuminis Health Anne Arundel Medical Center, Annapolis, MD, USA.
Jane C BrennanLuminis Health Anne Arundel Medical Center, Annapolis, MD, USA.
Matthew A PetermanLuminis Health Anne Arundel Medical Center, Annapolis, MD, USA.
Jeffrey GelfandLuminis Health Anne Arundel Medical Center, Annapolis, MD, USA.
Daniel E RedziniakLuminis Health Anne Arundel Medical Center, Annapolis, MD, USA.
Cyrus LashgariLuminis Health Anne Arundel Medical Center, Annapolis, MD, USA.
Justin J TurcotteLuminis Health Anne Arundel Medical Center, Annapolis, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Prior studies have shown that testosterone replacement therapy (TRT) may be a risk-factor for complications after rotator cuff repair (RCR). This study evaluated complication rates among male RCR patients with and without a history of TRT preoperatively. Methods: A retrospective review of 33,032 male patients undergoing RCR in the PearlDiver database was performed. Patients receiving TRT within 1-year of surgery were propensity score matched 1:3 to those not receiving TRT, 8,258 TRT, and 24,774 no-TRT patients were included. Univariate and multivariate analyses were performed to compare outcomes between groups. Results: After controlling for decreased libido, benign prostatic hypertrophy, tobacco use, alcohol disorders, liver disease, rheumatologic disease, and preoperative steroid injections, TRT patients were more likely to be readmitted within 90 days (odds ratio [OR]: 1.26, Conclusion: TRT within 1 year of RCR appears to be a risk factor for multiple postoperative complications and subsequent shoulder surgery. Cessation of TRT prior to RCR should be considered on a patient-specific basis.

Indexed as

Hormone replacement therapyPatient outcomesPostoperative complicationsRevision rotator cuff repairRotator cuff repairTestosterone replacement therapy

Identifiers

PMID41459022
PMCPMC12743503

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.