Evidence map›Paper›PMID 41458975›Full record

ArticleFrontiers in pharmacology2025

Impact of the diverse cardiotonic steroids on beta-amyloid precursor protein level.

Irina Yu Petrushanko, Denis R Lisitskii, Maria A Strelkova, Anna P Tolstova, Artemy P Fedulov, Filipp A Filonov, Vladimir A Mitkevich, Alexander A Makarov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Irina Yu PetrushankoEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Denis R Lisitskii *Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Maria A Strelkova *Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Anna P TolstovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Artemy P FedulovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Filipp A FilonovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Vladimir A MitkevichEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Alexander A MakarovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endogenous cardiotonic steroids (CTS), which are specific ligands of Na,K-ATPase, have been detected not only in blood plasma but also in cerebrospinal fluid and in the brain tissue. Consequently, the role of CTS in the central nervous system has gained increasing relevance. Na,K-ATPase serves not only as a receptor for CTS but also as a target for beta-amyloid (Aβ

Indexed as

APPbeta amyloidcardiotonic steroidsNa,K-ATPaseSrc kinase

Identifiers

PMID41458975
PMCPMC12738930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.