Evidence map›Paper›PMID 41458936›Full record

ArticleNeuro-oncology practice2025

Presenting clinical and radiographic features of diffuse glioma molecular subtypes in accordance with the 2021 CNS5 WHO classification.

Jasmin Jo, Mark Willy L Mondia, Josephine Arewa, Andrew How, James Patrie, Nicholas Dueck, Reed Gilbow, Andrew Goschka, David Joyner, Sohil H Patel and 2 more

Abstract read
In one paragraph

Article in Neuro-oncology practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jasmin JoDepartment of Internal Medicine, Division of Hematology Oncology, East Carolina University.ORCID https://orcid.org/0000-0003-3679-1206
Mark Willy L MondiaDepartment of Neurology, Division of Neuro-oncology, University of Virginia, Charlottesville, Virginia.
Josephine ArewaDepartment of Neurology, Division of Neuro-oncology, University of Virginia, Charlottesville, Virginia.
Andrew HowDepartment of Neurology, Division of Neuro-oncology, University of Virginia, Charlottesville, Virginia.
James PatrieDepartment of Public Health Sciences, University of Virginia.
Nicholas DueckDepartment of Radiology, University of Virginia, Charlottesville, Virginia.
Reed GilbowDepartment of Radiology, University of Virginia, Charlottesville, Virginia.
Andrew GoschkaDepartment of Radiology, University of Virginia, Charlottesville, Virginia.
David JoynerDepartment of Radiology, University of Virginia, Charlottesville, Virginia.
Sohil H PatelDepartment of Radiology, University of Virginia, Charlottesville, Virginia.
M Beatriz LopesDepartment of Pathology, Division of Neuropathology, University of Virginia, Charlottesville, Virginia.
David SchiffDepartment of Neurology, Division of Neuro-oncology, University of Virginia, Charlottesville, Virginia.ORCID https://orcid.org/0000-0002-1896-2502

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The incorporation of molecular parameters into WHO CNS5 has led to reclassification of gliomas. We describe presenting clinical and radiographic features of diffuse adult gliomas according to CNS5 category. Methods: We reviewed pathology reports, clinical and MRI data at presentation of 972 adult patients with glioma between January 2010 and February 2022. Continuous variables were presented as median; categorical variables as numbers and percentages. Comparison was performed using Fisher's exact test. Results: Seven hundred and thirty-six patients had sufficient data for CNS5 reclassification: Grade 2 IDH mutant (IDHmut) astrocytoma (A2) Conclusion: Significant differences in the clinical and radiographic features exist among CNS5 glioma subtypes, informing potential diagnosis, management and prognosis at initial presentation.

Indexed as

clinical presentationCNS5 classificationdiffuse gliomamolecular parametersradiographic features

Identifiers

PMID41458936
PMCPMC12741841

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.