Evidence map›Paper›PMID 41458886›Full record

ArticleInnovation in aging2025

Advanced topic modeling with large language models: analyzing social media content from dementia caregivers.

Weiqing He, Bojian Hou, Amy Zheng, Yanbo Feng, Ari Klein, Karen O'Connor, Shu Yang, Tianqi Shang, George Demiris, Graciela Gonzalez-Hernandez and 1 more

Abstract read
In one paragraph

Article in Innovation in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. DynamiCare: A Dynamic Multi-Agent Framework for Interactive and Open-Ended Medical Decision-Making.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Weiqing HeDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Bojian HouDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID https://orcid.org/0000-0002-3894-4547
Amy ZhengDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Yanbo FengDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Ari KleinDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID https://orcid.org/0000-0002-8281-3464
Karen O'ConnorDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Shu YangDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID https://orcid.org/0000-0002-8507-7191
Tianqi ShangDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID https://orcid.org/0009-0007-7147-0316
George DemirisDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID https://orcid.org/0000-0002-6318-5829
Graciela Gonzalez-HernandezDepartment of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, California, United States.
Li ShenDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID https://orcid.org/0000-0002-5443-0503

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: While traditional topic modeling methods have been applied to analyze social media content from dementia caregivers, they often struggle with semantic understanding and coherent topic generation. This study explores the direct application of large language models (LLMs) for topic modeling of caregiver tweets, aiming to leverage their advanced semantic comprehension capabilities. Research Design and Methods: We analyzed 231 870 tweets from dementia caregivers after preprocessing using ChatGPT as the primary topic modeling tool. To address context length limitations, we developed a 2-stage approach: first splitting the dataset into 226 batches of 1000 tweets each for initial topic extraction, then combining these results through a second-stage prompt for final topic synthesis. We compared our approach against 11 baseline methods, including Latent Dirichlet Allocation (LDA), Gibbs Sampling Dirichlet Multinomial Mixture Model (GSDMM), their term-weighted variants, and state-of-the-art BERTopic models. Topic quality was evaluated using Sentence-BERT-based coherence scores, and topic comprehensiveness was assessed through both ChatGPT and human expert evaluation. Results: Our LLM-based approach achieved a coherence score of 0.358, significantly outperforming all baseline methods. Traditional approaches like GSDMM (0.317) and LDA (0.320), their term-weighted variants (ranging from 0.264 to 0.302), and BERTopic variants (approximately 0.30) showed lower coherence scores. The 2-stage batching strategy effectively handled the large dataset while maintaining topic quality and representativeness. Expert evaluation confirmed the topics' relevance to caregiver experiences and their comprehensive coverage of key themes. Discussion and Implications: This study introduces a novel methodology for applying LLMs to large-scale topic modeling tasks, demonstrating superior performance over traditional and state-of-the-art approaches. The significant improvement in coherence scores suggests that LLMs can better capture the semantic relationships within topics. Our approach addresses key challenges in context length limitations and prompt engineering, while providing more coherent and interpretable insights into caregiver experiences that can inform targeted support strategies.

Indexed as

Healthcare informaticsNatural language processingPrompt engineeringSemantic coherenceSocial media analysis

Identifiers

PMID41458886
PMCPMC12742845

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.