Evidence map›Paper›PMID 41458871›Full record

ArticleCureus2025

Bridging the Wound Gap: Interim Results From Randomized Trials Evaluating Dehydrated Human Amnion-Intermediate Layer-Chorion Membrane for the Treatment of Non-healing Diabetic Foot Ulcers.

Hunter J Hall, Ann Keenan, Kurt Massey, Walter F D'Costa, Peter Moyer

Abstract read
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hunter J HallMedical School, The University of Toledo College of Medicine and Life Sciences, Toledo, USA.
Ann KeenanPodiatry, Purvis Foot and Ankle Center, Rocky Mount, USA.
Kurt MasseyAdvanced Foot and Ankle Center, Piedmont HealthCare, Mooresville, USA.
Walter F D'CostaPodiatry, Northern California Foot and Ankle Center of Santa Rosa, Santa Rosa, USA.
Peter MoyerPodiatry, Purvis Foot and Ankle Center, Rocky Mount, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction Patients with diabetes frequently develop diabetic foot ulcers, a significant clinical pathology that results in increased morbidity and mortality. Standard of care (SOC) treatment has been insufficient to prevent the poor outcomes associated with these wounds. This analysis aims to evaluate the supplementation of SOC with a human tissue allograft. Methods This evaluation is of two prospective, multicenter, randomized clinical studies (ELITE - ongoing and CAMPLIFE - terminated) comparing a dehydrated human amnion-intermediate layer-chorion membrane (dHAICM) tissue allograft (AmchoPlast

Indexed as

allograftchronic wound carediabetes mellitusdiabetic chronic woundsdiabetic foot ulcer (dfu)human placental tissueskin substitute

Identifiers

PMID41458871
PMCPMC12743229

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.