ArticleCureus2025
The Effective Ropivacaine Concentration for Transversus Thoracic Muscle Plane Block in Adult Cardiac Surgery: A Dose-Finding Trial Protocol.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Median sternotomy in cardiac surgery is associated with severe pain, and opioid-based analgesia is currently standard. In recent years, various ultrasound-guided nerve block types have been used in cardiac surgery to reduce opioid use and facilitate postoperative recovery, including ultrasound-guided transversus thoracic muscle plane block. However, the 90% effective concentration of ropivacaine used for ultrasound-guided transverse thoracic muscle plane block (TTPB) in cardiac surgery remains undetermined. This study aims to evaluate the 90% effective concentration of ropivacaine for ultrasound-guided transversus thoracic muscle plane block in adult cardiac surgery using the biased coin up-and-down sequential method. Methods This study is a single-center, prospective, sequential allocation dose-finding trial. Participants will be adult patients with American Society of Anesthesiologists physical status (ASA-PS) II-IV undergoing elective cardiac surgery with median sternotomy. Ultrasound-guided transversus thoracic muscle plane block will be performed after induction of general anesthesia at 0.4 ml.kg
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