ArticleCureus2025
Preventive Effect of Platelet-Rich Plasma on Fracture Healing in a Rat Tibial Nonunion Model: A Controlled Laboratory Experiment.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Platelet-rich plasma in cartilage repair: biological mechanisms and clinical perspectives.Frontiers in sports and active living · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Nonunion, defined as the absence of progressive healing for more than six months after fracture, remains a major challenge in orthopedic practice, leading to chronic pain, impaired mobility, and reduced quality of life. Platelet-rich plasma (PRP), an autologous concentrate of platelets and growth factors, has been proposed as a biological adjunct for enhancing tissue regeneration. Although PRP has been demonstrated as beneficial for acute fracture healing, its efficacy in established nonunion is unclear. Methods We established a rat tibial nonunion model by transverse osteotomy with circumferential periosteal removal and intramedullary fixation. Sixteen male Sprague-Dawley rats (10 weeks old) were randomly assigned to four groups (n = 4/group): Sham (osteotomy only), Nu (nonunion), Nu + PRP, and Nu + Vehicle (saline). Allogeneic pooled PRP was prepared by single centrifugation (200 × g, 7 min) for local injection (50 µL) immediately after surgery and at postoperative weeks 2 and 4. Motor function was assessed using the rotarod test, and bone healing was evaluated by micro-computed tomography (µCT) and histology (Emery fracture healing score) at postoperative week 6. Results Compared with whole blood, platelets were enriched approximately 2.5-fold in PRP (
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