ArticleFrontiers in oncology2025
Mechanism of action of Butein in cutaneous squamous cell carcinoma through regulation of the TWEAK-FN14 signaling pathway.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Polyphenols as Multi-Target Regulators of Oxidative Stress, Mitochondrial Function, and Cell Survival Signaling in Skin Diseases.International journal of molecular sciences · 2026Review
- Phytocompounds with immunomodulatory activities: mechanisms, therapeutic potential, and clinical prospects.Inflammopharmacology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The incidence of cutaneous squamous cell carcinoma (cSCC) continues to rise, while current therapeutic approaches remain limited in efficacy for patients with advanced disease. The natural polyphenol Butein has demonstrated antitumor activity in various malignancies; however, its role and underlying mechanisms in cSCC remain unclear. Our previous study revealed that the TWEAK-FN14 axis promotes cSCC proliferation by activating the NF-κB and STAT3 pathways, whereas Butein can inhibit both pathways, suggesting that it may exert anti-cSCC effects by targeting the TWEAK-FN14 axis. Objective: To investigate whether Butein affects cSCC growth by modulating the TWEAK-FN14 signaling pathway and its tumor microenvironment, and to elucidate the underlying molecular mechanisms. Results: Molecular docking predicted that Butein exhibits strong binding affinity with TWEAK, FN14, cIAP1, and TRAF1/2 proteins, with binding energies ranging from -5.8 to -6.9 kcal/mol. Conclusion: Butein effectively suppresses cSCC growth by directly binding to and inhibiting key proteins in the TWEAK-FN14 signaling pathway, thereby coordinately modulating the downstream inflammatory microenvironment. This study provides mechanistic insights and experimental evidence supporting Butein as a potential therapeutic candidate for cSCC.
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