SynthesisFrontiers in oncology2025
Effects of race and ethnicity on hematopoietic stem cell transplant outcomes in acute myeloid leukemia: a systematic review and meta-analysis.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Introduction: Despite the advancements in medical facilities and treatment, acute myeloid leukemia (AML) remains a significant concern. Hematopoietic stem cell transplantation (HSCT) is the preferred treatment option for AML. However, racial and ethnic disparities have a prominent impact on HSCT outcomes due to variability in treatment availability, transplant referral, donor scarcity, socioeconomic status, and other factors. Methods: In this systematic review and meta-analysis, we evaluated transplantation rates, relapse rates, and survival outcomes across racial and ethnic groups. A comprehensive search was conducted using PubMed, Embase, and Cochrane Library to screen relevant studies. Study quality was assessed using the MINORS scale and NIH tool, followed by an assessment of publication bias using the funnel plot and Egger's test. A random-effects model was employed to evaluate the transplantation rate, relapse rate, and overall survival (OS). Cochran's Q test and I2 statistic were utilized to assess the heterogeneity. Results: A total of 781 articles were screened, and following several stages of screening according to inclusion criteria, seven full-text articles comprising nine datasets were included in the final analysis. The pooled results for transplantation and OS were not statistically significant. However, the pooled results for relapse outcome were statistically significant for both Blacks vs. Whites (risk ratio [RR] = 1.17; 95% CI: 1.04-1.32; p=0.008; I Discussion: Minimizing disparities in the social determinants of health across racial and ethnic groups, along with providing equity in treatment access, are needed to improve outcomes. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420250644767, identifier CRD420250644767.
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