ReviewInternational journal of nanomedicine2025
Advances in Nano-Phototherapy for Targeted Fat Reduction: From Mechanisms to Clinical Translation in Obesity.
Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Obesity is a global public health concern, and traditional surgical interventions such as liposuction, although effective, carry risks of trauma and complications. Non-invasive phototherapies, including photobiomodulation therapy (PBMT), photodynamic therapy (PDT), and photothermal therapy (PTT), have emerged as promising alternatives. Methods: This narrative review synthesizes current literature on phototherapy-based fat reduction. A PubMed search was conducted using the terms ("photosensitive material" OR "photodynamic therapy" OR "photothermal" OR "photobiomodulation") AND ("lipolysis" OR "fat reduction" OR "body contour"). Of 105 studies meeting inclusion criteria, 80 were selected for detailed analysis, focusing on PBMT, PDT, and PTT in non-invasive fat reduction. Results: PDT induces adipocyte apoptosis and tissue remodeling via ROS generated by photosensitizers; PTT applies near-infrared light to heat adipose tissue, promoting fat cell death and enhancing local metabolic activity; PBMT stimulates mitochondrial activity, accelerating lipolysis and metabolic processes. Some studies indicate that the use of nanomaterials may modestly enhance targeting and therapeutic efficacy. Conclusion: Non-invasive phototherapy shows great potential in obesity management, and the integration of nanomaterials may further enhance targeting and therapeutic efficacy, enabling safer and more efficient fat reduction. Future studies should optimize phototherapy parameters and explore the synergistic effects of nanomaterials and personalized intervention strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.