ReviewFrontiers in endocrinology2025
Osteosarcopenia in metabolic dysfunction-associated steatotic liver disease: from mechanisms to management.
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Interorgan Crosstalk in MASLD: A Narrative Review.Biomedicines · 2026Review
- Review
- Genetically Predicted Muscle Mass and Function in Relation to Deep Vein Thrombosis: A Two-step Mendelian Randomization Study Highlighting the Mediating Role of BMI.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteosarcopenia, the coexistence of osteoporosis and sarcopenia, is an emerging and underrecognized complication in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). While muscle and bone loss have been individually observed in MASLD, their combined impact remains poorly addressed in clinical practice. This review outlines the epidemiology, pathophysiological mechanisms, clinical relevance, and current strategies for diagnosing and managing osteosarcopenia in MASLD. Shared pathogenic pathways, including insulin resistance, chronic inflammation, hormonal imbalance, and gut dysbiosis, create a vicious cycle contributing to musculoskeletal degradation and liver disease progression. We highlight the need for proactive screening of osteosarcopenia, and using standardized assessment tools. A multidimensional therapeutic approach, encompassing nutrition, exercise, pharmacotherapy, and emerging metabolic and gut-targeted interventions, may improve not only musculoskeletal health but also hepatic and systemic outcomes. Future studies are warranted to improve long-term prognosis for both osteosarcopenia and MASLD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.