Evidence map›Paper›PMID 41458547›Full record

ArticleFrontiers in endocrinology2025

Association of early and mid-pregnancy maternal serum uric acid with hypertensive disorders of pregnancy.

Chang Zou, Ruru Zhao, Xiaosong Liu, Yuanyuan Yang, Qinxin Shen, Qiaoling Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chang Zou *Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Ruru Zhao *Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiaosong LiuShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Yuanyuan YangShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Qinxin ShenShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Qiaoling DuShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To examine association between maternal serum uric acid (UA) measured during gestational 4-24 weeks and the subsequent development of hypertensive disorders of pregnancy (HDP) in a large Chinese cohort. Methods: This historical cohort study included 84,298 singleton pregnancies registered at Shanghai First Maternity and Infant Hospital (2013-2022). Serum UA was measured before 24 weeks of gestation. Participants with pre-existing hypertension or incomplete data were excluded. Generalized additive models (GAMs) and multivariable logistic regression analyses were used to assess nonlinear and independent associations between UA levels (quartiles and continuous values) and risks of gestational hypertension (GH), preeclampsia (PE), and overall HDP cases, adjusting for maternal age, pre-pregnancy BMI, education, and glucose metabolism disorders. Results: UA levels were consistently higher among women who later developed HDP than in normotensive pregnancies throughout gestational weeks 4-24. Higher UA concentrations consistently associated with an increased risk of HDP diseases, the top UA quartile showed the strongest associations with GH (1.82, 1.59-2.08), PE (1.67, 1.48-1.89), and total HDP (1.77, 1.61-1.94). GAM analyses revealed enhanced relation of UA to HDP occurrence from the 4 Conclusions: Elevated maternal UA levels in early-to-mid gestation independently related to HDP risk, with subtype-specific and gestational-age-dependent patterns. UA serves as a practical potential biomarker for early risk stratification and dynamic monitoring of women at risk for hypertensive complications.

Indexed as

Hypertension, Pregnancy-InducedUric AcidAdultBiomarkersChinaCohort StudiesFemaleGestational AgeHumansPre-EclampsiaPregnancyPregnancy Trimester, SecondRisk FactorsBiomarkersUric Acideclampsiagestational hypertension (GH)preeclampsiapregnancy-induced hypertensionuric acid

Identifiers

PMID41458547
PMCPMC12740876

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.