ArticleFrontiers in medicine2025
Application of thromboelastogram and coagulation function in evaluating coagulation status of pregnant women across different trimesters.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
Authors and funding
5 authors.
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Abstract
Background: Pregnancy induces a hypercoagulable state to prevent hemorrhage during delivery, but it also increases the risk of thrombotic events and postpartum hemorrhage. Monitoring coagulation changes is essential to ensure maternal and fetal health. Thromboelastography (TEG), which provides a detailed assessment of the coagulation cascade, remains underutilized across all stages of pregnancy. Methods: This retrospective study included 92 pregnant women grouped by trimester (30 in the first, 34 in the second, and 28 in the third), and 30 non-pregnant women as controls. Standard coagulation metrics [prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB)] and TEG parameters (R, K, Results: As pregnancy progressed, PT, APTT, and TT decreased, while Fibrinogen levels increased significantly compared to the control group ( Conclusion: Significant changes in both TEG and traditional coagulation parameters throughout pregnancy reflect the development of a hypercoagulable state. The integration of TEG with standard tests offers a comprehensive approach for detecting coagulation abnormalities early, improving perinatal outcomes. These findings are descriptive of physiological adaptation and do not support routine TEG screening in healthy pregnancies.
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