Evidence map›Paper›PMID 41458454›Full record

ReviewCommunications materials2025

Meta-analyses of the evolution of MXene synthesis for bioengineering and artificial intelligence-driven applications.

Leena Regi Saleth, Mehak Gupta, Gautam Sharma, Elika Verma, Sanjiv Dhingra

Abstract readReview
In one paragraph

Review in Communications materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Leena Regi SalethInstitute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, Biomedical Engineering Program, University of Manitoba, Winnipeg, MB R2H 2A6 Canada.ORCID 0000-0001-5075-1820
Mehak GuptaInstitute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, Biomedical Engineering Program, University of Manitoba, Winnipeg, MB R2H 2A6 Canada.
Gautam SharmaInstitute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, Biomedical Engineering Program, University of Manitoba, Winnipeg, MB R2H 2A6 Canada.ORCID 0000-0003-3321-637X
Elika VermaInstitute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, Biomedical Engineering Program, University of Manitoba, Winnipeg, MB R2H 2A6 Canada.
Sanjiv DhingraInstitute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, Biomedical Engineering Program, University of Manitoba, Winnipeg, MB R2H 2A6 Canada.ORCID 0000-0002-2664-7633

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The year 2011 marked a breakthrough in material science innovation with the discovery of MXenes, an emerging family of two-dimensional transition metal-based nanomaterials. Owing to their distinctive properties, MXenes have rapidly surfaced as transformative materials, particularly in energy-storage and nanomedicine. In this review, we systematically explore the evolution of MXene synthesis, from its discovery to current advancements, focussing on their bioengineering applications, through a meta-analytic and bibliometric lens. We discuss synthesis methods, ranging from hydrofluoric acid (HF)-based etching to non-HF approaches, along with post-synthesis processes like intercalation, delamination and surface functionalization, that tailor MXene properties for biomedical therapeutics. We also overview key microscopy, spectroscopy and diffraction-based characterization methods, to understand their structure and functionality. Additionally, discussion on artificial intelligence (AI)-driven innovations highlights the significant shift in material science. By connecting synthesis methods with resulting characteristics and meta-analyses trends, this review emphasizes MXenes' transformative potential in regenerative therapeutics and diagnostics.

Indexed as

ImmunologySynthesis and processing

Identifiers

PMID41458454
PMCPMC12738290

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.