ReviewJournal of inflammation research2025
Comprehensive Review of Sepsis-Related Skeletal Muscle Atrophy: Mechanisms, Diagnosis and Therapeutic Strategies.
Review in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Sarcopenia and Frailty in COPD: Mechanisms, Relationship with Malnutrition and Potential Therapeutic Interventions.Nutrients · 2026Review
- Crosstalk between innate immune signaling pathways and integrated TLR, NLRP3 inflammasome, cGAS-STING, and NF-κB networks in sepsis.Frontiers in cell and developmental biology · 2026Review
- Sepsis in multimorbidity: a domain-based framework for systemic vulnerability and precision care.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This comprehensive review aims to synthesize current evidence on sepsis-related skeletal muscle atrophy, with a focus on underlying mechanisms, diagnostic approaches, and therapeutic interventions. A systematic literature search was conducted in PubMed, Web of Science, and Cochrane Library up to October 2024, including clinical, translational, and animal studies. We critically analyzed the pathophysiological mechanisms linking sepsis to muscle wasting, including inflammatory signaling, mitochondrial dysfunction, and proteolytic pathways. Epidemiological data indicate a high incidence of muscle atrophy in sepsis patients, particularly among the elderly and those with comorbidities. Diagnostic modalities such as CT, MRI, ultrasound, and emerging biomarkers including urinary titin and myokines are discussed. Treatment strategies encompassing nutritional support, pharmacotherapy (eg, GLP-1RAs, myostatin inhibitors), and rehabilitation are evaluated. Controversies regarding etiology and treatment efficacy are highlighted. Future directions include the exploration of novel biomarkers, genomics-based personalized therapy, and long-term outcome studies. This review provides a structured and critical appraisal of the current state of knowledge, aiming to inform clinical practice and future research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.