Evidence map›Paper›PMID 41458340›Full record

ArticleCureus2025

Outcomes and Determinants of Coronary Endarterectomy With Coronary Artery Bypass Graft (CABG): A Tertiary Centre's Five-Year Experience.

Nada Ali, Francesca Gatta, Mahmoud Elkhatib, Neeraj Mediratta

Abstract read
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nada AliCardiothoracic Surgery, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, GBR.
Francesca GattaCardiothoracic Surgery, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, GBR.
Mahmoud ElkhatibCardiothoracic Surgery, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, GBR.
Neeraj MedirattaCardiothoracic Surgery, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, GBR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary endarterectomy (CE) is used as an adjunct to coronary artery bypass grafting (CABG) in patients with severe diffuse coronary artery disease. The primary goal of performing CE is to achieve complete revascularisation by recreating a patent lumen when isolated CABG is not possible due to severe plaque burden. This study evaluates outcomes following CE-CABG at a tertiary centre and uniquely examines how vessel type, operative technique may influence mortality. Additionally, it highlights the heterogeneity in prescribing anti-thrombotic medications post-operatively.  Methods: We analysed urgent and elective CE-CABG procedures from 2019 to 2024, excluding patients with concomitant valve surgery or incomplete records. The primary objective was to assess short- and mid-term survival after coronary endarterectomy combined with CABG at a tertiary centre. Secondary objectives included postoperative complications, changes in heart function, and the impact of anatomical and technical factors on outcome. Survival was estimated with Kaplan-Meier analysis.

resultsThe cohort comprised 48 patients (mean age 66.5 ± 9.1 years, 81.3% male), with high rates of dyslipidaemia (79.2%) and hypertension (62.5%). Most procedures were urgent (68.8%) and performed on-pump (72.9%). In-hospital mortality was 8.3%, and overall mortality during follow-up was 20.8%. Prolonged inotropic support (47.9%), extended ventilation (41.7%), and atrial fibrillation (20.8%) were the most common complications. Mortality differed by vessel: obtuse marginal (OM) endarterectomy demonstrated the highest mortality rate (42.9%), whereas left anterior descending (LAD) endarterectomy showed comparatively lower mortality (16.7%). Open endarterectomy was associated with numerically lower mortality (15%) compared with closed techniques. Considerable heterogeneity was observed in postoperative antithrombotic prescribing across the cohort. Kaplan-Meier curves demonstrated a high early postoperative risk with stable survival in the mid-term period.

conclusionsCE-CABG carries notable early morbidity and mortality, but mid-term survival remains acceptable. This study highlights vessel- and technique-specific risk, though the limited statistical power and absence of standardised perioperative protocols constrain generalisability. Larger studies are needed to refine patient selection, optimise surgical approach, and standardise antithrombotic strategies following CE.

Indexed as

coronary artery bypass grafting (cabg)coronary endarterectomy (ce)diffuse coronary artery diseasemid-term survivalpostoperative outcomes

Identifiers

PMID41458340
PMCPMC12739972

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.