Evidence map›Paper›PMID 41458263›Full record

ArticleOxford medical case reports2025

Paraneoplastic progressive Supranuclear palsy: a case report and literature review.

Kaoutar Simma, Asmae Sikkal, Hajar Khattab, Kamal Haddouali, Salma Bellakhdar, Bouchra E L Moutawakil, Mohamed Abdoh Rafai, Hicham E L Otmani

Abstract readCase Reports
In one paragraph

Article in Oxford medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaoutar SimmaHassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca, Rue Tarik Ibn Ziad, Casablanca 20100, Morocco.ORCID https://orcid.org/0009-0001-5573-3784
Asmae SikkalHassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca, Rue Tarik Ibn Ziad, Casablanca 20100, Morocco.ORCID https://orcid.org/0009-0009-3774-5704
Hajar KhattabHassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca, Rue Tarik Ibn Ziad, Casablanca 20100, Morocco.ORCID https://orcid.org/0000-0001-8124-7651
Kamal HaddoualiHassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca, Rue Tarik Ibn Ziad, Casablanca 20100, Morocco.ORCID https://orcid.org/0009-0002-5656-8669
Salma BellakhdarHassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca, Rue Tarik Ibn Ziad, Casablanca 20100, Morocco.ORCID https://orcid.org/0000-0002-4580-2774
Bouchra E L MoutawakilHassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca, Rue Tarik Ibn Ziad, Casablanca 20100, Morocco.ORCID https://orcid.org/0009-0004-1208-8449
Mohamed Abdoh RafaiHassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca, Rue Tarik Ibn Ziad, Casablanca 20100, Morocco.ORCID https://orcid.org/0000-0002-4342-7499
Hicham E L OtmaniHassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca, Rue Tarik Ibn Ziad, Casablanca 20100, Morocco.ORCID https://orcid.org/0000-0003-0870-1808

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progressive supranuclear palsy-Richardson syndrome (PSP-RS) is a sporadic atypical parkinsonian disorder typically resistant to levodopa. While most cases are neurodegenerative, various conditions (genetic, vascular, infectious, or paraneoplastic) can mimic this phenotype, termed PSP-like or PSP mimics. Although paraneoplastic PSP is extremely rare, it is important to recognize because of its potential reversibility. The diagnosis can be particularly challenging, especially when classical tumor markers or imaging fail to identify a clear neoplastic origin. Here, we describe a 39-year-old man with an Anti-Ri-mediated PSP-like syndrome in whom an extensive evaluation, including surgical removal of two suspicious sites (thymus and testis), failed to identify an underlying tumor. The patient presented with rapidly progressive symptoms characteristic of PSP-RS, raising clinical suspicion for a paraneoplastic cause. We also review the literature on paraneoplastic PSP.

Indexed as

anti Riatypical parkinsonismautoimmune movement disordersparaneoplastic syndromeprogressive supranuclear palsyPSP like syndromes

Identifiers

PMID41458263
PMCPMC12741441

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.