Evidence map›Paper›PMID 41458259›Full record

ArticleMaterials today. Bio2026

NIR-II-responsive conductive silk fibroin microneedle patches for postoperative melanoma ablation, infected-wound healing, and real-time monitoring.

Haimeng Liu, Zhuangwei Chen, Chunting Zhang, Yuhang Gao, Zhonghao Zhao, Xiaolu Guo, Wenguo Sun, Xiaohua Huang, Li Zhou, Chanjuan Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. NIR-Assisted Multimodal Strategies for Enhanced Antibacterial Therapy.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haimeng LiuGuangxi Colleges and Universities Key Laboratory of Natural and Biomedical Polymer Materials, Guangxi Key Laboratory of Optical and Electronic Materials and Devices, and College of Materials Science and Engineering, Guilin University of Technology, Guilin, 541004, China.
Zhuangwei ChenGuangxi Colleges and Universities Key Laboratory of Natural and Biomedical Polymer Materials, Guangxi Key Laboratory of Optical and Electronic Materials and Devices, and College of Materials Science and Engineering, Guilin University of Technology, Guilin, 541004, China.
Chunting ZhangGuangxi Colleges and Universities Key Laboratory of Natural and Biomedical Polymer Materials, Guangxi Key Laboratory of Optical and Electronic Materials and Devices, and College of Materials Science and Engineering, Guilin University of Technology, Guilin, 541004, China.
Yuhang GaoGuangxi Colleges and Universities Key Laboratory of Natural and Biomedical Polymer Materials, Guangxi Key Laboratory of Optical and Electronic Materials and Devices, and College of Materials Science and Engineering, Guilin University of Technology, Guilin, 541004, China.
Zhonghao ZhaoGuangxi Colleges and Universities Key Laboratory of Natural and Biomedical Polymer Materials, Guangxi Key Laboratory of Optical and Electronic Materials and Devices, and College of Materials Science and Engineering, Guilin University of Technology, Guilin, 541004, China.
Xiaolu GuoState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, 541001, China.
Wenguo SunDepartment of Urology, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, China.
Xiaohua HuangGuangxi Colleges and Universities Key Laboratory of Natural and Biomedical Polymer Materials, Guangxi Key Laboratory of Optical and Electronic Materials and Devices, and College of Materials Science and Engineering, Guilin University of Technology, Guilin, 541004, China.
Li ZhouGuangxi Colleges and Universities Key Laboratory of Natural and Biomedical Polymer Materials, Guangxi Key Laboratory of Optical and Electronic Materials and Devices, and College of Materials Science and Engineering, Guilin University of Technology, Guilin, 541004, China.
Chanjuan LiuGuangxi Colleges and Universities Key Laboratory of Natural and Biomedical Polymer Materials, Guangxi Key Laboratory of Optical and Electronic Materials and Devices, and College of Materials Science and Engineering, Guilin University of Technology, Guilin, 541004, China.
Xing-Can ShenState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, 541001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postoperative management of melanoma remains a significant clinical challenge due to the concurrent risks of residual tumor recurrence, bacterial infection, impaired healing, and the lack of real-time monitoring. Here, we presented an all-in-one theranostic microneedle patches (MNs) engineered from a natural biomaterial framework. The patch is fabricated via photo-crosslinking of methacrylated silk fibroin (SFMA) and acrylated β-cyclodextrin (Ac-CD), which incorporates lignosulfonate-doped poly-N-phenylglycine (LS@PNPG) nanocomposites as multifunctional photothermal and conductive components, alongside β-cyclodextrin-encapsulated curcumin (Cur) for hydrophobic drug delivery. The optimized MNs exhibited robust mechanical strength (1.73 N per needle), ensuring reliable skin penetration. The LS@PNPG component exhibited a high NIR-II photothermal conversion efficiency (30.65 % at 1064 nm), enabling effective photothermal heating (>58 °C in vitro; ∼50 °C in vivo) that triggered on-demand Cur release. This synergistic photothermal-chemotherapy achieved 98.9 % tumor eradication in vivo. Concurrently, the patch demonstrated potent antioxidant (87.2 % DPPH scavenging) and antibacterial activities (>98 % elimination of

Indexed as

Hydrogel microneedlesInfected wound regenerationNIR-II-ResponsivenessPhotothermal-chemotherapy synergyReal-time monitoringSilk fibroin

Identifiers

PMID41458259
PMCPMC12741391

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.