ReviewFrontiers in dental medicine2025
Angiogenic regulation of dental pulp stem cells.
Review in Frontiers in dental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Targeting Dental Pulp Stem Cell Senescence: A Potential Strategy for Improving Regenerative Endodontic Procedures.Bioengineering (Basel, Switzerland) · 2026Article
- The light at the other end of the tunnel: heeding two decades of regeneration research to reclaim natural tooth preservation.Frontiers in bioengineering and biotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue regeneration relies on the ingrowth of blood vessels from the host for the survival and functionalization of regenerated tissues. Any holdup in this process can threaten the viability of the transplanted progenitor cells, which in turn can hinder effective tissue regeneration. Dental pulp stem cells (DPSCs) are a promising candidate cell source for dental pulp regeneration due to their potential for odontogenic and endothelial differentiation, as well as angiogenic properties. This narrative review examines the mechanisms by which DPSCs regulate angiogenesis. DPSCs modulate angiogenesis through multiple mechanisms: direct differentiation into endothelial cells, paracrine secretion of angiogenic growth factors, and functioning as mural cells to stabilise the nascent vasculature formed. Furthermore, the physical and biological interaction between DPSCs and extracellular matrices modulate the process of angiogenesis. The primary focus is on the intricate, multifaceted aspects of dental pulp regeneration; however, broader aspects of general tissue regeneration were also highlighted. The angiogenic modulation by DPSCs holds significant potential for the formulation of strategies that integrate pro-angiogenic scaffolds and signalling molecules to address the challenges associated with dental pulp tissue regeneration.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.