Evidence map›Paper›PMID 41458148›Full record

ArticleBlood vessels, thrombosis & hemostasis2026

Mitochondrial arginase 2 regulates hematopoietic and cardiovascular adaptation to hypoxia.

Weiling Xu, Kewal Asosingh, Allison J Janocha, Evan Madden, Nicholas Wanner, Dylan Trotter, Michael V Novotny, Anny Mulya, Ruoying Chen, Samar Farha and 1 more

Abstract read
In one paragraph

Article in Blood vessels, thrombosis & hemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Weiling XuDepartment of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Kewal AsosinghDepartment of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Allison J JanochaDepartment of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Evan MaddenDepartment of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Nicholas WannerDepartment of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Dylan TrotterDepartment of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Michael V NovotnyDepartment of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Anny MulyaDepartment of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Ruoying ChenDepartment of Quantitative Health Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Samar FarhaDepartment of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Serpil C ErzurumDepartment of Inflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.

Funding

NITRIC OXIDE PRODUCTION AND REACTIONS IN THE LUNGR01HL060917 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Serpil C. Erzurum · 1999 to 2026
$6.3M
Cleveland Clinic integrative behavior-single cell proteomics workflowS10OD025207 · OD · CLEVELAND CLINIC LERNER COM-CWRU · PI DESILVA, TARA MARIA · 2019 to 2019
$745k
NHLBI NIH HHS R01 HL060917NIH HHS S10 OD025207
6 · The paper itself

Abstract

Physiological adaptation to hypoxia involves coordinated responses of the hematopoietic and cardiovascular systems to maintain tissue oxygenation. Arginine metabolism, via nitric oxide synthases and arginases, modulates both erythropoiesis and vascular tone. Arginase 2 (

Identifiers

PMID41458148
PMCPMC12741383

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.