ArticleFrontiers in neurology2025
Association between systemic immune-inflammation index at admission and post-stroke depression in patients with acute ischemic stroke.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between systemic immune-inflammation index and post-stroke depression: a meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Molecular biomarkers of cognitive impairment and neuropsychiatric symptoms after stroke in late-life-enriched cohorts: a scoping review.Journal of translational medicine · 2026Article
- Inflammatory profiling for precision neurorehabilitation after traumatic brain injury and stroke: a narrative review.Frontiers in neurology · 2026Review
- Identifying key predictors of post-stroke depression and cognitive impairment in acute stroke survivors.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Post-stroke depression (PSD) is one of the most common neuropsychiatric complications among stroke survivors, with a substantial impact on functional recovery and quality of life. This study aimed to investigate the association between the systemic immune-inflammation index (SII) at admission and the occurrence of PSD in patients with acute ischemic stroke (AIS). Methods: We prospectively enrolled 318 consecutive patients with first-ever AIS admitted to our hospital between August 2024 and March 2025. Venous blood samples were collected at admission, and SII was calculated as neutrophil count × platelet count/lymphocyte count. At 3 months post-stroke, depressive symptoms were assessed using the 17-item Hamilton Depression Rating Scale (HAMD-17). Patients with a HAMD-17 score >7 were diagnosed with PSD and categorized accordingly into PSD and non-PSD groups. Results: At the 3-month follow-up, 98 patients (30.82%) were diagnosed with PSD. Compared with the non-PSD group, patients in the PSD group had significantly higher SII values [658.66 (468.73-958.90) vs. 476.71 (362.73-646.83), Conclusion: Elevated SII levels at admission are positively associated with the development of PSD in AIS patients, suggesting that SII may serve as a valuable inflammatory biomarker for early identification of patients at high risk for PSD.
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