ArticleRheumatology and immunology research2025
Features of IgG4-related sclerosing mesenteritis: A Chinese cohort study and literature review.
Article in Rheumatology and immunology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Management of IgG4-Related Disease.Current rheumatology reports · 2026Review
- Natural history, clinical associations, and management issues of idiopathic sclerosing mesenteritis: a prospective cohort study.Gastroenterology report · 2026Article
- Clinical associations, outcomes, and therapeutic management of patients with symptomatic sclerosing mesenteritis.Therapeutic advances in gastroenterology · 2026Article
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Authors and funding
11 authors.
Funding
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Abstract
Objectives: This study aimed to summarize the features of IgG4-related sclerosing mesenteritis (IgG4-SM) based on both our large prospective IgG4-related disease (IgG4-RD) cohort and literature-reported IgG4-SM cases. Methods: We applied a mixed-methods approach, integrating data from 29 patients with IgG4-SM and 87 matched IgG4-RD patients without mesenteritis, all enrolled in a prospective cohort of IgG4-RD from Peking Union Medical College Hospital (PUMCH) since 2011. Additionally, we included 32 IgG4-SM cases reported in public databases since 2011. Demographic, clinical, laboratory, imaging and treatment data were systematically compared. Results: Compared with IgG4-RD without mesenteritis, IgG4-SM predominantly affected elderly males and accompanied with more organ involvement ( Conclusions: IgG4-SM is a significant but under-recognized manifestation of IgG4-RD, characterized by a predilection for elderly males, multi-organ involvement, higher disease activity and distinct imaging features. Systemic radiological evaluation, including PET-CT could assist diagnosis and treatment monitoring. Glucocorticoid-based therapy achieved outcomes comparable to surgery, challenging the necessity of invasive interventions. This study expands the clinical spectrum of IgG4-SM and advocates for personalized, non-surgical management strategies in most cases.
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