ArticleRheumatology and immunology research2025
CD209 gene polymorphism and its clinical correlation with susceptibility to rheumatoid arthritis among Egyptian patients: A case-control study.
Article in Rheumatology and immunology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Objectives: Certain genetic traits increase the likelihood of developing rheumatoid arthritis (RA); nevertheless, the association between RA and polymorphisms in the CD209 gene is ambiguous. This study sought to investigate the correlation between RA susceptibility and the CD209 single nucleotide polymorphisms rs4804803 (AG) and rs735239 (AG) within the Egyptian population. Methods: This case-control study was conducted between January and October 2024 and included 108 participants. Of these, 54 patients were diagnosed with RA according to the 2010 classification criteria of the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). Two CD209 promoter regions rs4804803 (-336A/G) and rs735239 (-871A/G) were genotyped for single nucleotide polymorphisms (SNPs) using multiplex polymerase chain reaction (PCR) and double amplification refractory system (dARMS). Results: Patients with RA showed significantly higher frequencies of the CD209 rs4804803 SNP in the AG ( Conclusions: This work highlights the significant role of the CD209 rs4804803 polymorphism, particularly the G allele, in the elevated susceptibility to RA among Egyptians.
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