ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Apathy, depression, and dementia risk in older adults: A global collaborative study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Depression as a prognostic factor for conversion from mild cognitive impairment to all-cause dementia and Alzheimer's disease: a systematic review and meta-analysis of longitudinal studies.Frontiers in public health · 2026Pooled it
- Visual Working Memory in Older Adults With and Without Early-Onset Depression: An Ecological Momentary Assessment Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- [Progress on prognostic assessment methods for mild cognitive impairment].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Review
- Apathy, depression, and dementia risk in older adults: A global collaborative study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Abstract
introductionThe role of apathy in predicting dementia risk, especially with coexisting depression, remains unclear in community-dwelling older adults.
methodsWe analyzed data from 12,646 older adults without baseline dementia across ten population-based cohorts from six continents (Cohort Studies of Memory in an International Consortium study). Apathy, depression, and dementia outcomes were assessed using harmonization protocols.
resultsOver 5.7 years of follow-up, 1160 developed dementia and 552 Alzheimer's disease (AD). Apathy prevalence was 34.1% and more than three times higher in those with depression. Apathy was not associated with dementia risk among cognitively normal or non-depressed individuals. In contrast, among individuals with depression and mild cognitive impairment (MCI), apathy predicted a higher risk of dementia (hazard ratio [HR] 1.62) and AD (HR 1.74). DISCUSSION: Apathy is associated with increased dementia risk only in older adults with MCI and depression. Findings highlight the need to incorporate affective symptom monitoring into dementia risk assessment and intervention. HIGHLIGHTS: Harmonized data from 10 population-based cohorts across six continents were used. Apathy predicted dementia only in older adults with both depression and mild cognitive impairment. No association was found in non-depressed or cognitively normal individuals. Monitoring progression of affective symptoms may aid dementia risk stratification.
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