ArticleACS applied materials & interfaces2026
Analyzing the Relationship between Solid-Phase Molecular Presentation and Cell Proliferation, Morphology and Secretion Using CellStudio.
Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Precise control over the spatial presentation of molecular cues is essential to engineer functional cell microenvironments. We previously developed CellStudio, a bead-based microsystem that combines cell patterning with localized biosensing, a cell analysis platform for monitoring cell secretion with spatial resolution. In this study, we extend its capabilities to investigate how the solid-phase presentation of fibroblast growth factor 2 influences cell behavior. By customizing the ratio of fibroblast growth factor 2-functionalized microbeads surrounding patterned mesenchymal stem cells clusters, we demonstrate dose-dependent effects on cell proliferation, survival, and morphology. Solid-phase fibroblast growth factor 2 presentation induced cytoskeletal remodeling, increased cell spreading and elongation, and early upregulation of fibroblast growth factor receptor 1 membrane expression. Additionally, we show that local fibroblast growth factor 2 stimulation enhances the secretion of vascular endothelial growth factor, which was
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