ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2026
Linking Planar Cell Polarity to Mechanotransduction During Morphogenesis.
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Wnt Signaling Across Adult Skin Mini-Organs: Interfollicular Epidermis, Hair Follicle, and Nail-Implications for Disease and Regeneration.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Mechanical forces provide essential cues for morphogenetic processes during embryonic development. Coordinated orientation of cells in the plane of epithelia, that is known as planar cell polarity (PCP), is also required for morphogenesis. How PCP is established and what role PCP signaling plays in tissue rearrangements remains poorly understood. Here, we review the evidence for a positive regulatory loop that connects PCP to mechanotransduction, the process by which cells convert mechanical stimuli, such as pressure or tension, into biochemical signals. Accumulating data strongly support a hypothesis that a PCP axis can form in response to intrinsic or extrinsic mechanical stresses. Moreover, we suggest that PCP signaling functions to control physical force production in the tissue. This mechanochemical feedback regulation is proposed to be a fundamental mechanism that ensures proper tissue shape and positioning during morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.