Trial reportJournal of cosmetic dermatology2026
Differential Therapeutic Efficacy of Autologous Platelet-Rich Plasma at Varying Concentrations in the Treatment of Deep Second-Degree Burn and Its Underlying Molecular Mechanisms.
Trial report in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Exploration of the Therapeutic Protocols and Underlying Molecular Mechanisms of Autologous Platelet-Rich Plasma in the Treatment of Deep Second-Degree Burns.Journal of cosmetic dermatology · 2026Trial
- Differential Therapeutic Efficacy of Autologous Platelet-Rich Plasma at Varying Concentrations in the Treatment of Deep Second-Degree Burn and Its Underlying Molecular Mechanisms.Journal of cosmetic dermatology · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundPlatelet-rich plasma (PRP) shows promise in burn management, yet optimal platelet concentrations, timing, and standardized protocols remain unclear, leading to inconsistent clinical outcomes.
aimsTo compare the therapeutic efficacy of PRP at different platelet concentrations in deep second-degree burns and to explore associated molecular mechanisms. PATIENTS/
methodsTwenty-eight patients with small-area deep second-degree burns were randomly assigned to four groups: Group A (PRP 600-1000 × 10
resultsAll PRP groups showed faster healing and lower infection rates compared with controls. Group C achieved the shortest healing time (p < 0.05). Growth factor concentrations rose with increasing platelet levels, but M2 macrophage polarization was highest in Group C. Elevated transforming growth factor-β (TGF-β) in Group D appeared to trigger negative feedback, limiting M2 accumulation and diminishing added benefit. Scar scores did not differ significantly among PRP groups.
conclusionsPRP accelerates wound healing and reduces infection risk in deep second-degree burns. A platelet concentration of 1000-1400 × 10
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Registered trials
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