Evidence map›Paper›PMID 41457459›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity.

Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaojiang LaiPrecision Research Center for Refractory Diseases, State Key Laboratory of Innovative Immunotherapy, Institute for Clinical Research, Shanghai Key Laboratory of Pancreatic Diseases, Department of Gastrointestinal Surgery, Department of Gastroenterology, Department of Nursing, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Guihong PanDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China.
Xixi FengState Key Laboratory of Respiratory Disease, the GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, 511436, China.
Jun ZhangPrecision Research Center for Refractory Diseases, State Key Laboratory of Innovative Immunotherapy, Institute for Clinical Research, Shanghai Key Laboratory of Pancreatic Diseases, Department of Gastrointestinal Surgery, Department of Gastroenterology, Department of Nursing, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Yunxia LiPrecision Research Center for Refractory Diseases, State Key Laboratory of Innovative Immunotherapy, Institute for Clinical Research, Shanghai Key Laboratory of Pancreatic Diseases, Department of Gastrointestinal Surgery, Department of Gastroenterology, Department of Nursing, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Shanmeizi ZhaoDepartment of Reproductive Medicine, Affiliated Jinling Hospital, Medical School, Nanjing University, Nanjing, 210002, China.
Zhenming LinReproductive Medicine Center, Yuebei People's Hospital, Shantou University Medical College, Shaoguan, 512026, China.
Yun FengPrecision Research Center for Refractory Diseases, State Key Laboratory of Innovative Immunotherapy, Institute for Clinical Research, Shanghai Key Laboratory of Pancreatic Diseases, Department of Gastrointestinal Surgery, Department of Gastroenterology, Department of Nursing, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Wei BaoPrecision Research Center for Refractory Diseases, State Key Laboratory of Innovative Immunotherapy, Institute for Clinical Research, Shanghai Key Laboratory of Pancreatic Diseases, Department of Gastrointestinal Surgery, Department of Gastroenterology, Department of Nursing, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Hongyan YangPrecision Research Center for Refractory Diseases, State Key Laboratory of Innovative Immunotherapy, Institute for Clinical Research, Shanghai Key Laboratory of Pancreatic Diseases, Department of Gastrointestinal Surgery, Department of Gastroenterology, Department of Nursing, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Chengmei XiePrecision Research Center for Refractory Diseases, State Key Laboratory of Innovative Immunotherapy, Institute for Clinical Research, Shanghai Key Laboratory of Pancreatic Diseases, Department of Gastrointestinal Surgery, Department of Gastroenterology, Department of Nursing, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Chen HuangPrecision Research Center for Refractory Diseases, State Key Laboratory of Innovative Immunotherapy, Institute for Clinical Research, Shanghai Key Laboratory of Pancreatic Diseases, Department of Gastrointestinal Surgery, Department of Gastroenterology, Department of Nursing, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Jun WangPrecision Research Center for Refractory Diseases, State Key Laboratory of Innovative Immunotherapy, Institute for Clinical Research, Shanghai Key Laboratory of Pancreatic Diseases, Department of Gastrointestinal Surgery, Department of Gastroenterology, Department of Nursing, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.ORCID https://orcid.org/0000-0003-4322-1551

Funding

General Projects sponsored by Natural Science Foundation of Shanghai 25ZR1401302National High-Level Talents Special Support Program Youth PanelNational Natural Science Foundation of China 32070918National Natural Science Foundation of China 82072662National Natural Science Foundation of China 82203751National Natural Science Foundation of China 82402100National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine NRCTM(SH)-2025-05Outstanding Youth Fund of Guangdong Province 2022B1515020109Shanghai General Hospital 02.06.01.23.169
6 · The paper itself

Abstract

Regulatory T cells (Tregs) can thrive in the harsh tumor microenvironment (TME) to dampen antitumor immunity. Chronic stresses within TME compromise canonical cap-dependent translation (CDT), which compromises effector T cell function but not Treg persistence. Death-associated protein 5 (DAP5/eIF4G2), a non-classical translational scaffold, has been reported to support human Treg differentiation in vitro, but its functions in thymic Treg development, peripheral Treg homeostasis, and tumor-infiltrating Treg (ti-Treg) fitness remain unclear. Here, it is shown that DAP5 expression positively correlates with ti-Treg frequencies in both colorectal cancer patients and murine subcutaneous tumors. Mice with homozygous Dap5 deletion in Tregs has intact thymic and peripheral Treg development but spontaneously developed typical scurfy symptoms. Haploinsufficiency of Dap5 in Tregs preserves peripheral immune homeostasis while suppressing tumor growth, with enhanced CD8

Indexed as

Colorectal NeoplasmsEukaryotic Initiation Factor-4GT-Lymphocytes, RegulatoryAnimalsHumansMiceMice, Inbred C57BLTumor MicroenvironmentEukaryotic Initiation Factor-4GDAP5/eIF4G2immune homeostasistranslationTregstumor microenvironment

Identifiers

PMID41457459
PMCPMC12915102

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.