Evidence map›Paper›PMID 41457449›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Sleep duration promotes resistance and resilience to tau in older women at risk for Alzheimer's disease.

Jordan Stiver, Xin Wang, Kitty K Lui, Melanie A Dratva, Ella T Lifset, Nadine C Heyworth, Charlotte S Rivera, Atul Malhotra, Michael L Thomas, Erin E Sundermann and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Menopausal insomnia as a modifiable node of dementia risk: Mechanistic insights and intervention strategies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  3. Article
  4. Sleep duration promotes resistance and resilience to tau in older women at risk for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jordan StiverDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Xin WangDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Kitty K LuiSan Diego Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, California, USA.
Melanie A DratvaDepartment of Psychology, University of California, Los Angeles, California, USA.
Ella T LifsetDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Nadine C HeyworthDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Charlotte S RiveraDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Atul MalhotraDivision of Pulmonary, Critical Care, Sleep Medicine & Physiology, Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Michael L ThomasDepartment of Psychology, Colorado State University, Fort Collins, Colorado, USA.
Erin E SundermannDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Sarah J BanksDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.

Funding

Biological and lifestyle factors contributing to Tau in women at risk for Alzheimer's disease.R01AG080663 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SARAH BANKS, Erin elizabeth Sundermann · 2023 to 2026
$4.2M
California Department of Public Health 19-10613NIA NIH HHS R01 AG080663NIA NIH HHS R01AG080663
6 · The paper itself

Abstract

introductionResistance and resilience are pathways through which modifiable behaviors may reduce Alzheimer's disease (AD) risk. Sleep - a known modifiable factor - is understudied in this context, especially among older women at elevated risk for AD.

methodsForty-five functionally intact older women (≥65 years) at heightened risk for AD completed wrist actigraphy to capture average nocturnal sleep duration. Tau positron emission tomography imaging (

resultsShorter sleep duration amplified the association between APOE ε4 status and tau, while longer sleep mitigated it. Similarly, tau burden was related to worse memory performance only among those with short sleep duration. DISCUSSION: Longer sleep duration may promote resistance and resilience to AD in at-risk older women, highlighting sleep as a critical intervention target. HIGHLIGHTS: Sleep was measured via wrist actigraphy, tau via PET imaging, and memory with a composite score. Longer sleep attenuated the link between APOE ε4 carriership and tau PET across Braak regions. Greater sleep duration weakened the negative impact of tau on memory performance. This is the first study to examine sleep in AD resistance and resilience among older women at heightened risk.

Indexed as

Alzheimer DiseaseSleeptau ProteinsActigraphyAgedAged, 80 and overApolipoprotein E4FemaleHumansPositron-Emission TomographyRisk FactorsSleep DurationApolipoprotein E4tau ProteinsactigraphyAlzheimer's diseaseAPOE ε4memorymodifiable lifestyle factorsolder womenresilienceresistancesex differencessleep durationtau PET

Identifiers

PMID41457449
PMCPMC12745661

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.