Evidence map›Paper›PMID 41457317›Full record

ArticleApplied and environmental microbiology2026

Contrasting pH optima of β-lactamases CTX-M and CMY influence

Mikkel Anbo, Saria Otani, Mirena Ivanova, Hanne Nørgaard Nielsen, Jacob Dyring Jensen, Christina Aaby Svendsen, Chengfang Pang, Frank M Aarestrup

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mikkel AnboDTU National Food Institute, Technical University of Denmark, Lyngby, Denmark.ORCID 0000-0002-0685-1055
Saria OtaniDTU National Food Institute, Technical University of Denmark, Lyngby, Denmark.ORCID 0000-0002-2538-8086
Mirena IvanovaDTU National Food Institute, Technical University of Denmark, Lyngby, Denmark.ORCID 0000-0002-0077-5207
Hanne Nørgaard NielsenDTU National Food Institute, Technical University of Denmark, Lyngby, Denmark.
Jacob Dyring JensenDTU National Food Institute, Technical University of Denmark, Lyngby, Denmark.
Christina Aaby SvendsenDTU National Food Institute, Technical University of Denmark, Lyngby, Denmark.
Chengfang PangDTU National Food Institute, Technical University of Denmark, Lyngby, Denmark.
Frank M AarestrupDTU National Food Institute, Technical University of Denmark, Lyngby, Denmark.ORCID 0000-0002-7116-2723

Funding

European Union Horizon 2020 874735Novo Nordisk Fonden NNF16OC0021856
6 · The paper itself

Abstract

Antimicrobial resistance is one of the largest and most pressing global health threats. This is not only a huge burden on the global economy but also a growing threat to animal, environmental, plant, and human health, and new strategies are needed to avoid resistance and improve treatment. Novel antimicrobial resistance genes are normally first detected once they cause problems in clinical infections, and we have limited knowledge on their evolutionary trajectories. Current antimicrobial susceptibility testing and research have a limited focus on key environmental factors in pathogen-reservoir-host interactions, possibly leading to inaccurate results that do not reflect the

Indexed as

Anti-Bacterial Agentsbeta-LactamasesEscherichia coliEscherichia coli ProteinsGenetic FitnessAnimalsHydrogen-Ion ConcentrationMicrobial Sensitivity TestsAnti-Bacterial Agentsbeta-lactamase CMY-2beta-lactamase CTX-M-15beta-lactamase CTX-M, E colibeta-LactamasesEscherichia coli Proteinsantimicrobial resistanceCMY-2CTX-M-15microbial ecologypHselectionβ-lactamases

Identifiers

PMID41457317
PMCPMC12863049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.