ArticleBMC microbiology2025
Emergence and hospital dissemination of hypervirulent carbapenem-resistant Klebsiella pneumoniae lineages in eastern China.
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Caerin 1.1/1.9 Inhibits Growth and Biofilm Formation of Carbapenem-Resistant Klebsiella pneumoniae and Induces Coordinated Transcriptomic Stress Responses.Current microbiology · 2026Article
- Multicenter Surveillance ofInfection and drug resistance · 2026Article
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9 authors.
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Abstract
backgroundCarbapenem-resistant Klebsiella pneumoniae (CRKP) presents a significant public health challenge globally, particularly due to the emergence of lineages with hypervirulent traits. Despite considerable impacts, the genomic epidemiology and evolutionary dynamics of CRKP, including classical CRKP, carbapenem-resistant hypervirulent K. pneumoniae (CR-hvKP), and hypervirulent carbapenem-resistant K. pneumoniae (hv-CRKP), remain poorly understood.
methodsWe performed a retrospective genomic epidemiology analysis on 131 CRKP isolates collected from a tertiary teaching hospital in Zhejiang Province, China, from 2010 to 2025. All isolates were subjected to antimicrobial susceptibility testing and whole-genome sequencing, followed by phylogenetic analysis and comprehensive characterization of resistance genes, virulence factors, and mobile genetic elements (MGEs).
resultsPhylogenetic analysis revealed 23 sequence types (STs), with ST11 (50.38%), ST15 (17.56%), and ST23 (7.63%) predominating. Nearly half (49.62%) of these isolates were hypervirulent, subdivided into 15 CR-hvKP (mainly ST23, predominant in 2013-2017) and 50 hv-CRKP isolates (mainly ST11, predominant since 2019). The hv-CRKP isolates exhibited cross-ward hospital dissemination capabilities superior to CR-hvKP strains. Additionally, hv-CRKP demonstrated resistance profiles comparable to classical CRKP but higher resistance rates to aminoglycosides, fluoroquinolones, and tetracyclines than CR-hvKP. Genetic analyses revealed substantial diversity in resistance genes, virulence factors, and MGEs among these CRKP lineages. The hv-CRKP strains notably carried a higher load of prophages and plasmids compared to classical CRKP and CR-hvKP, suggesting an expanded genomic repertoire that may enhance their evolutionary adaptability.
conclusionsOur findings underscore the adaptive evolution and increasing dominance of hv-CRKP within hospital settings, highlighting the urgent need for intensified surveillance and intervention strategies to curb the spread of these highly virulent and resistant pathogens.
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