ArticleBMC women's health2025
Causal relationship between diet and common female diseases: a comprehensive Mendelian randomization study.
Article in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Mediterranean diet adherence and metabolic parameters in women with polycystic ovary syndrome: a retrospective cross-sectional study.BMC women's health · 2026Article
- Global Burden of Ovarian Cancer and Causal Risk Factors from 1990 to 2021: An Integrated GBD and Mendelian Randomization Analysis.International journal of women's health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectiveThis study aimed to investigate the causal relationship between dietary habits and nine common diseases with high female prevalence using a two-sample Mendelian randomization (MR) approach.
methodsDrawing upon pooled Genome-Wide Association Study (GWAS) data from European cohorts, this research interrogated genetic associations across 21 detailed dietary classifications and nine major diseases with high prevalence in women.
resultsOur study identified multiple associations between dietary factors and gynecological disease risks. In initial analyses, dried fruit was inversely associated with breast and cervical cancer, while beef increased breast cancer risk. Endometrial cancer risk was linked to coffee, alcohol, and non-oily fish. Ovarian cancer risk exhibited mixed associations, rising with alcohol and non-oily fish but decreasing with pork, dried fruit, and beef. Among benign conditions, risk associations were observed for ovarian cysts (positive with omelette/whole-wheat; negative with coffee/lobster/dark chocolate/dried fruit), endometriosis (positive with shellfish; negative with coffee/cheese), uterine fibroids (coffee, dried fruit, non-oily fish), premature ovarian failure (protective: soya dessert; risk: herbal tea, dark chocolate, whole-wheat), and polycystic ovary syndrome (fresh fruit, yogurt, herbal tea). However, after false discovery rate (FDR) correction for multiple testing, only two associations remained significant: dried fruit intake with a reduced risk of breast cancer and coffee intake with an increased risk of uterine fibroids.
conclusionOur comprehensive MR analysis yields insights into the potential causal links between dietary factors and common diseases in women, paving the way for non-pharmacological public health interventions. The findings highlight the potential of dietary modifications as a preventative measure against the onset of these conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.