Evidence map›Paper›PMID 41457187›Full record

ArticleNeuroscience bulletin2026

SIGMAR1 Drives the Development of Neuropathic Pain by Promoting AMPA Receptor Membrane Trafficking Through Interacting with NPTX1 in Male Mice.

Jie Ren, Yasi Zheng, Wu Yang, Xueli Yin, Guanxi Liu, Ting Xu, Jianbo Zhang, Wenjun Xin, Xueqin Zhang, Suyan Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jie Ren *The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, 510182, China.
Yasi Zheng *Department of Anesthesiology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China.
Wu Yang *The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, 510182, China.
Xueli YinThe Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, 510182, China.
Guanxi LiuThe Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, 510182, China.
Ting XuNeuroscience Program of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Jianbo ZhangDepartment of Pain Medicine, The Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Wenjun XinNeuroscience Program of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Xueqin ZhangThe Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, 510182, China. gzzxq2005@126.com.
Suyan LinDepartment of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China. linsy33@foxmail.com.ORCID http://orcid.org/0000-0003-1769-2683

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early intervention in neuropathic pain can effectively delay its chronicity. Sigma non-opioid intracellular receptor 1 (SIGMAR1) is upregulated in the spinal dorsal horn during the development of spared nerve injury (SNI)-induced neuropathic pain. Methylated RNA immunoprecipitation confirmed that the SIGMAR1 upregulation was driven by mRNA N

Indexed as

C-Reactive ProteinNerve Tissue ProteinsNeuralgiaReceptors, AMPAReceptors, sigmaAnimalsHyperalgesiaMaleMiceMice, Inbred C57BLNeuronsPentraxinsProtein TransportSigma-1 ReceptorC-Reactive ProteinNerve Tissue ProteinsPentraxinsReceptors, AMPAReceptors, sigmaSigma-1 ReceptorGluA1Neuropathic painNPTX1SIGMAR1Spinal dorsal horn

Identifiers

PMID41457187
PMCPMC13221534

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.