ArticleMolecular psychiatry2026
Structural covariance, regional topology, and volumetric aspects of amygdala subnuclei in posttraumatic stress disorder using ultra-high field imaging.
Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The amygdala is a subcortical brain structure involved in threat processing and implicated in various psychopathology. Previous efforts to map amygdala subnuclei connectivity have been hindered by technological limitations. This study used ultra-high field imaging to investigate the covariance profiles of amygdala subnuclei to better understand their contribution to trauma-related psychopathology and posttraumatic stress disorder (PTSD). Participants included 59 non-trauma-exposed controls (NEC; 51% female), 78 trauma-exposed controls (TEC; 65% female), and 73 individuals with PTSD (93% female) who completed T1-weighted MP2RAGE anatomical scans using a 7-Tesla MRI scanner. FreeSurfer was used to parcellate 105 brain regions including nine bilateral amygdala subnuclei. Pearson's r correlations were computed for each subnuclei-brain region pair, corrected for age, sex, education, and total brain volume. Gray matter volumes, topological connectivity (nodal degree) using graph analysis, and subnuclei-brain region covariances were compared between-groups. There were between-group volumetric differences for the lateral nuclei (left: NEC < PTSD/TEC; right: PTSD < NEC/TEC), and higher nodal degree of the right paralaminar subnucleus for TEC (vs NEC). Covariance patterns differed between-groups, with lower PTSD (vs NEC) structural covariances for left cortical and central nuclei, and higher TEC (vs NEC) covariances for left lateral, basal, cortical, and anterior-amygdaloid-area, right cortico-amygdaloid transition, and bilateral paralaminar nuclei. This study is the first to reveal differences in amygdala subnuclei covariance profiles along the trauma-spectrum using ultra-high field imaging. Findings suggest that amygdala subnuclei could have differential connectivity profiles in trauma-related conditions and ultra-high field imaging studies are needed to more precisely understand their role.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.