Evidence map›Paper›PMID 41457064›Full record

ArticleScientific reports2025

The prevalence and predictors of non-alcoholic fatty liver disease in Chinese patients with inflammatory bowel disease: a multicenter retrospective study.

Yonghua Shen, Feng Liang, Qingqing Li, Yan Zhang, Chong Fu, Xiaoming Sun, Haijue Ge, Weidong Fan, Ying Xie, Chunyan Peng and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yonghua Shen *Department of Gastroenterology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, China.
Feng Liang *Department of Gastroenterology, Huai'an Second People's Hospital, The Affiliated Hospital of Xuzhou Medical University, Huai'an, China.
Qingqing Li *Department of Gastroenterology, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, China.
Yan ZhangDepartment of Gastroenterology, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
Chong FuDepartment of Gastroenterology, Anqing Municipal Hospital, Anqing, China.
Xiaoming SunDepartment of Gastroenterology, Anqing Municipal Hospital, Anqing, China.
Haijue GeDepartment of Gastroenterology, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hospital, Yancheng, China.
Weidong FanDepartment of Gastroenterology, Zhangjiagang First People's Hospital, Zhangjiagang Affiliated Hospital of Soochow University, Zhangjiagang, China.
Ying XieDepartment of Gastroenterology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, China.
Chunyan PengDepartment of Gastroenterology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, China.
Lei WangDepartment of Gastroenterology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, China.
Baojie WenDepartment of Ultrasound, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, China. wenbaojie@hotmail.com.
Weiping HuangDepartment of Gastroenterology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China.
Lili ZhangDepartment of Gastroenterology, The Affiliated Wuxi Second People's Hospital of Nanjing Medical University, Wuxi, China. dg1735099@smail.nju.edu.cn.
Xiaoqi ZhangDepartment of Gastroenterology, Affiliated Hospital of Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, China. zhangxiaoqinj@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) has a higher prevalence in inflammatory bowel disease (IBD) patients compared to the general population. Herein, the prevalence and predictors of NAFLD in a large IBD cohort were evaluated by non-invasive method. A multicenter retrospective study was conducted among 592 inpatients diagnosed with IBD who underwent abdominal ultrasound. Characteristics of IBD and metabolic status were collected, presence of hepatic steatosis was assessed, and predictors for NAFLD were analyzed. A total of 509 IBD patients were included in the final analysis including 245 NAFLD (48.1%) subjects. IBD patients with NAFLD were older than those without NAFLD. NAFLD patients had more diabetes, higher body mass index (BMI) and more obesity. The patients with NAFLD showed increased levels of gamma-glutamyl transferase, uric acid, glycemia, triglycerides and low density lipoprotein. The localization of ulcerative colitis showed a more extensive trend in NAFLD patients compared with non-NAFLD subjects. Multivariate analysis showed that NAFLD was independently associated with BMI levels, biologic agents using, and prior surgery in IBD patients. NAFLD is common in Chinese patients with IBD. Obesity and biologics using are risk factors, and prior intestinal surgery is a protective factor of NAFLD development. These findings should be interpreted in the context of an inpatient-based study population.

Indexed as

Inflammatory Bowel DiseasesNon-alcoholic Fatty Liver DiseaseAdultAgedBody Mass IndexChinaEast Asian PeopleFemaleHumansMaleMiddle AgedObesityPrevalenceRetrospective StudiesRisk FactorsDisease activityInflammatory bowel diseaseNon-alcoholic fatty liver diseaseNon-invasive methodSteatosis

Identifiers

PMID41457064
PMCPMC12774897

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.