Evidence map›Paper›PMID 41456906›Full record

ArticleGlia2026

Acute Intermittent Hypoxia Exerts Beneficial Effects and Promotes Repair in Male Mice in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.

Nataliya Tokarska, Josh Roberts, Sameer Rathnayaka Koralage, Justin M A Naniong, Jayne M Johnston, Zelan Wei, Valerie M K Verge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Beneficially Stressing the Peripheral Nervous System to Repair.International journal of molecular sciences · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nataliya TokarskaDepartment of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Josh RobertsDepartment of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Sameer Rathnayaka KoralageDepartment of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Justin M A NaniongDepartment of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Jayne M JohnstonDepartment of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Zelan WeiDepartment of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Valerie M K VergeDepartment of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.ORCID 0000-0001-6648-3242

Funding

CIHR PJT - 183666Multiple Sclerosis Society of Canada 2362Multiple Sclerosis Society of Canada 920566University of Saskatchewan College of Graduate and Postdoctoral Studies Teaching ScholarshipUniversity of Saskatchewan College of Medicine Graduate Research Award (CoMGRAD)University of Saskatchewan College of Medicine Research Award (CoMRAD)
6 · The paper itself

Abstract

Multiple sclerosis (MS) affects women more frequently than men, but the disease progresses more aggressively in men. We have demonstrated that acute intermittent hypoxia (AIH), a noninvasive therapy, promotes repair and remyelination and alters disease course in the female MOG

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalHypoxiaMultiple SclerosisAnimalsDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMyelin-Oligodendrocyte GlycoproteinRemyelinationMyelin-Oligodendrocyte Glycoproteinaxon protectionmacrophagemicrogliamultiple sclerosismyelinationoligodendrocyteoligodendrocyte precursor cell

Identifiers

PMID41456906
PMCPMC12745063

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.