Evidence map›Paper›PMID 41456900›Full record

ArticleInternational journal of spine surgery2025

Efficacy and Safety of Lag Screw Fixation in Unstable Hangman's Fractures: A Systematic Review and Meta-analysis.

Mohammad Ghorbani, Michael Karsy, Saeid Esmaeilian, Seyed Ali Moshtaghioon, Bardia Hajikarimloo, Shaghayegh Karami, Mohammad Sina Mirjani, Mohammad Amin Habibi, Elham Rahmanipour, Mohammad Ali Abouei Mehrizi and 3 more

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Article in International journal of spine surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mohammad GhorbaniOrthopedic Research Center, Department of Orthopaedics Surgery, Mashhad University of Medical Sciences, Mashhad, Iran.
Michael KarsyDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Saeid EsmaeilianDepartment of Radiology, Shiraz University of Medical Sciences, Shiraz, Fars, Iran.
Seyed Ali MoshtaghioonDepartment of Orthopedic and Trauma Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Bardia HajikarimlooDepartment of Neurosurgery, University of Virginia, USA.
Shaghayegh KaramiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Sina MirjaniClinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
Mohammad Amin HabibiClinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
Elham RahmanipourImmunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad Ali Abouei MehriziMashhad University of Medical Sciences, Mashhad, Iran drabouei@yahoo.com.
Khushal GuptaBharat Ratna Late Shri Atal Bihari Vajpayee Memorial Govt Medical College, Chhattisgarh, India.
Golnaz Golrokhian SaniFaculty of dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahyar DaskarehDepartment of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesHangman's fracture, caused by high-energy hyperextension with axial loading trauma, remains challenging to manage. Unstable types (IIa and III) can be treated by a variety of surgical options. Lag-screw fixation has recently gained attention owing to its compatibility with navigation, minimally invasive instrumentation, and lower surgical morbidity.

methodsA systematic review and meta-analysis of surgical efficacy and safety of lag screw fixation was undertaken. Nine studies, which included a total of 128 patients, assessed outcomes of lag screw fixation, including neck range of motion, intervertebral angle (C2-C3), postoperative pain (visual analog scale), intraoperative parameters, and complications.

resultsSignificant improvements were observed in pooled range of motion (extension: 6.28°, flexion: 5.13°) and correction of the C2 to C3 angle by -3.54° (

conclusionC2 transpedicular lag-screw fixation restores alignment and preserves motion with low reported complications in available case series. Larger comparative trials are needed to define its role relative to fusion techniques. CLINICAL RELEVANCE: Direct osteosynthesis of unstable hangman's fractures via lag-screw fixation offers a viable motion-preserving alternative to C2-C3 fusion. By avoiding fusion, this technique maintains physiological cervical biomechanics and reduces the risk of adjacent segment disease. However, clinicians must carefully weigh these benefits against the technical demands of screw placement and the current lack of high-level comparative evidence. LEVEL OF EVIDENCE: 4:

Indexed as

Hangman’s fracturelag screw fixationspinal alignmentsurgical outcomes

Identifiers

PMID41456900
PMCPMC12800644

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.