ArticleIndian pacing and electrophysiology journal
Influence of pulmonary vein ovality on the occlusion efficacy of a size-adjustable cryoballoon: Insights from a 3D silicone model study.
Article in Indian pacing and electrophysiology journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Shape matters: Pulmonary vein ovality as a determinant of cryoballoon occlusion efficacy.Indian pacing and electrophysiology journalArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCryoballoon ablation is an established therapy for atrial fibrillation, but complete pulmonary vein (PV) occlusion can be challenging in large or anatomically complex veins. The size-adjustable cryoballoon (POLARx™ FIT), expandable to 31 mm, was developed to improve occlusion; however, downsizing to a 28-mm balloon is sometimes required. The impact of PV morphology, particularly ovality, on occlusion performance remains unclear.
methodsIn vitro PV models with long-axis diameters of 30 mm and 24 mm were created, each including multiple ovality indices. Occlusion was assessed using 28-mm and 31-mm POLARx™ FIT cryoballoons. Intraluminal PV pressure was measured as an index of occlusion efficacy, with three repeated measurements averaged for each model.
resultsFor the 31-mm balloon, a significant negative correlation was observed between ovality index and PV pressure in both model sizes (p < 0.0001), indicating reduced occlusion with increasing ovality. No such correlation was observed for the 28-mm balloon. In 24-mm models, the 28-mm balloon achieved higher and more consistent pressures.
conclusionPre-freeze mechanical occlusion differed according to balloon size and PV geometry. The 31-mm balloon performed best in larger, more circular veins, whereas the 28-mm balloon showed more uniform performance across varying shapes, likely reflecting differences in stiffness and compliance. These findings provide mechanistic insight into balloon-PV interactions and warrant further experimental and clinical validation.
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