ArticleJournal of fluorescence2026
A Phenazine-Based Fluorescent Probe with Imidazoline-2-Thione for Rapid and Selective Detection of HOCl in Living Cells.
Article in Journal of fluorescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- In-Situ Encapsulation of AIEgens in Nanoconfined Pores Over MOFs for High-Resolution Recognition of 3-Level Latent Fingerprint.Journal of fluorescence · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
Hypochlorous acid (HOCl) is a reactive oxygen species involved in both host defense and pathological processes, making its detection in biological systems of critical importance. Herein, we report the design and synthesis of a phenazine-based fluorescent probe, PNN, incorporating an imidazoline-2-thione recognition unit for selective HOCl detection. PNN exhibits a distinct "turn-on" fluorescence at 555 nm upon reaction with HOCl, with an enhancement of approximately 108-fold, surpassing that of previously reported thione-based probes, which typically emit in the 445-505 nm range. PNN also shows high sensitivity, rapid response, and excellent selectivity over other reactive oxygen and nitrogen species. Furthermore, PNN displays negligible cytotoxicity in HeLa cells and enables concentration-dependent visualization of exogenous HOCl in living cells. These features position PNN as a robust and reliable tool for monitoring HOCl in complex biological environments, providing a versatile platform for investigating its physiological and pathological functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.